How To Store
Reasonable price for immune cell cryopreservation?
The freezing storage fee is directly related to the freezing storage period, the freezing storage magnitude, and the attached individualized application rights. It is also related to the technical level and service level of the freezing storage institution. It is recommended to choose the appropriate freezing storage institution and service rights according to personal health needs.
The fundamental purpose of cryopreservation is to prepare for possible use in the future, and the rapid development of cell technology, the popularization of application is a major trend, therefore, it is recommended not to only consider the price of pure cryopreservation, but to comprehensively consider the feasibility, reliability and convenience of future applications. sex.
For young people, it is definitely better to freeze in advance when the immune cells are in the best state than for middle-aged and elderly people. In addition to considering the availability of applications, it is also possible to choose a frozen storage institution that can pay in installments; for middle-aged and elderly people, In other words, it is best to choose an institution that can perform comprehensive and accurate physical examination and application while cryopreserving, so as to timely intervene in sub-health or improve and delay the progression of chronic diseases, and the cost-effectiveness will be higher.
Today's cells are always better than tomorrow's!
Healthy cells are always better than diseased ones!
Provide healthy seeds for future use of immune cells!
The fundamental purpose of cryopreservation is to prepare for possible use in the future, and the rapid development of cell technology, the popularization of application is a major trend, therefore, it is recommended not to only consider the price of pure cryopreservation, but to comprehensively consider the feasibility, reliability and convenience of future applications. sex.
For young people, it is definitely better to freeze in advance when the immune cells are in the best state than for middle-aged and elderly people. In addition to considering the availability of applications, it is also possible to choose a frozen storage institution that can pay in installments; for middle-aged and elderly people, In other words, it is best to choose an institution that can perform comprehensive and accurate physical examination and application while cryopreserving, so as to timely intervene in sub-health or improve and delay the progression of chronic diseases, and the cost-effectiveness will be higher.
Today's cells are always better than tomorrow's!
Healthy cells are always better than diseased ones!
Provide healthy seeds for future use of immune cells!
Are there any contraindications to immune cell cryopreservation?
Collection and cryopreservation are recommended under optimal human health. Generally, the following conditions should be excluded before collection and cryopreservation:
• Age ≥ 70 years old;• Some infectious diseases (such as HIV, syphilis, hepatitis virus in the replication phase);
• Patients with autoimmune diseases and collagen diseases (such as systemic lupus erythematosus, dermatitis, scleroderma, etc.);
• Whole blood and blood components transfused within the past five years;
• Less than half a year after major surgery;
• Childbirth and breastfeeding less than 1 year;
• Those with anemia or dyslipidemia;
• Certain chronic inflammatory skin diseases, etc.
• Under the normalization of the epidemic situation, COVID-19 antibodies are also a mandatory inspection item for infectious disease factors.
Can frozen immune cells be used by my family?
Due to the biological characteristics of immune cells, in order to avoid clinical risks such as rejection, autologous use is recommended. Allogeneic use requires strict HLA matching (ie, matching criteria for bone marrow transplant and organ transplant).
Can children freeze immune cells?
Although there is no age limit for cryopreservation, because the immune cells of minors are not fully developed and are still in a "trained" state, it is generally recommended to cryopreserve after the age of 18.
How long can immune cells be stored?
Theoretically, it can be frozen permanently.
Studies have shown that cryopreservation can make cells in a dormant state, all enzymes in cells are inhibited, and ionization damage will not occur, so long-term cryopreservation is possible. Cells can be stored frozen at -70°C for up to one year. And frozen in liquid nitrogen at -196 ℃, from the theoretical analysis of cryogenic biology, the freezing time of liquid nitrogen is infinite.There are many case reports at home and abroad of the use of cryopreserved cells for more than ten years for effective clinical applications. In February 2021, the United States used the cells of the endangered black-footed ferret, which was cryopreserved in 1988, and successfully cloned a cell after resuscitation. Only live black-footed ferrets, cryopreservation for 33 years does not affect cell activity and function at all!
Why freeze immune cells in advance?
Clinical experts do advocate cryopreserving immune cells when young or healthy, and extracting them as needed when old or sick:
Generally speaking, the number and activity of immune cells that determine human immunity reach the highest peak at the age of 18-20, only half of the peak at the age of 40, and only about 1/10 of the peak at the age of 70.
Clinical studies have also shown that when you are sick (or the reason for being sick), the number and activity of immune cells in the human body decrease compared to healthy ones, or there are certain defects.
Who is suitable for cryopreservation of immune cells?
From the perspective of scientific planning of family health management, people who want to improve sub-health, delay aging, improve immunity, and prevent and treat tumors can consider freezing immune cells. including but not limited to:
• People with a family history of cancer;
• Early-stage cancerous population;
• Occupational groups frequently exposed to carcinogens or hazardous environments;
• People with bad living habits;
• People who want to improve their immunity;
• People who need anti-aging beauty or health care;
• Healthy people aged 18-65.
• People with a family history of cancer;
• Early-stage cancerous population;
• Occupational groups frequently exposed to carcinogens or hazardous environments;
• People with bad living habits;
• People who want to improve their immunity;
• People who need anti-aging beauty or health care;
• Healthy people aged 18-65.
What is immune cell cryopreservation?
Immune cells refer to cells involved in or related to immune responses, and are also commonly known as white blood cells, including T cells, B cells, NK cells, and DC cells that we often hear about.
Immune cell cryopreservation is the collection of autologous peripheral blood. After passing the test, immune cells are isolated and extracted in a standard GMP laboratory, and then the cells are placed in a -196°C ultra-low temperature liquid nitrogen tank through a fully automated programmed cooling process. It is stored frozen and can be extracted at any time when needed.
Immune cell cryopreservation is the collection of autologous peripheral blood. After passing the test, immune cells are isolated and extracted in a standard GMP laboratory, and then the cells are placed in a -196°C ultra-low temperature liquid nitrogen tank through a fully automated programmed cooling process. It is stored frozen and can be extracted at any time when needed.
What is the difference between cryopreserving immune cells and "freezing cord blood"?
Both cryopreserved cell types, goals, and intended uses are different.
Immune cells are cryopreserved in the form of peripheral blood mononuclear cells (PBMCs), mainly including T cells, B cells, DC cells, NK cells, phagocytes and other immune cells of a small number of cell types.Immune cells are the "defense force" that protects our health. This force can defend against invading pathogens such as pathogenic bacteria and viruses, and clean up senescent cells and mutated cells such as cancer cells in the body, thereby maintaining our health. Therefore, cryopreserved immune cells can be used to improve sub-health, anti-aging, prevent and treat tumors in the future.
The so-called "cryopreservation of umbilical cord blood" refers to the isolation and cryopreservation of hematopoietic stem cells from umbilical cord blood, and hematopoietic stem cell transplantation can be used to treat leukemia and so on.
What is the use of frozen immune cells?
Cryopreserved immune cells can be extracted at any time, and the number can be expanded after resuscitation, targeted selection or transformation for application. There are generally six clinical uses as follows:
01 Prevent Cancer
Cancer is a chronic disease. It usually takes 5-8 years from the earliest gene mutation to cell mutation to canceration of organs and tissues. For people who have found gene mutations or cell mutations in clinical accurate physical examination, immune cells can be used to improve immunity or directly eliminate them. Mutated cells for early prevention.02 Cure Cancer
When unfortunately suffering from cancer, the extracted immune cells can be modified against the cancer cell antigen, amplified and then reinfused, so as to accurately remove cancer cells in the body and achieve the goal of cancer treatment. For example, CAR-T preparations, which have been hotly discussed recently as "astronomical anti-cancer drugs", are based on this principle, using transformed and expanded T cells (CAR-T drugs use T cells after cancer, whose quality and quantity are Not as good as frozen when healthy, so it takes longer and costs more to prepare).03 Prevent Cancer Recurrence
Binding the patient's own cancer cell antigens to immune cells, amplified and then infused back, is equivalent to allowing the immune system to generate memory, and once cancer cells appear again, they will be recognized and eliminated immediately.04 Anti-aging, Beauty
Immune cells can clean up senescent somatic cells in a timely manner, thereby delaying the aging process.05 Precise Protection Of Prgans
Regulatory T cells in the immune cell population can precisely protect organs, such as organ transplantation, myocardial infarction, etc.06 Improve Ommunity, Improve Sub-health
Sub-health is the critical point where the human body is between health and disease. Sub-health symptoms are also warning signals sent by the body. If you don't pay attention, it may progress to disease. Immune cell reinfusion can improve the body's immunity and improve the sub-health state.
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